More recently, it was reported that the functional inhibition of TG2 fibronectin-binding domain suppresses the formation of complex between TG2, fibronectin, and β1-integrin, and reduces spheroid formation [107]; in this case, TG2 promotes ovarian CSCs survival also through the Wnt/β-catenin pathway, by direct interaction with Wnt receptor Frizzled 7 (Fzd7), that is generally upregulated in ovarian cancer with respect to normal ovarian epithelium [107]. Here, TGM2 is linked to ovarian carcinoma.