The panel of proteins identified as discriminating between the groups, included peptides known to be involved in the modulation of weight change/insulin sensitivity over time in individuals with and without T2DM, such as IGF-II [13,14], RBP4 [15,16,17], Fetuin-A [18,19], ZA2G-Zinc-α2-glycoprotein [20], Visfatin [21,22,23] and FAS-Fatty acid synthase [24,25,26]. The gene discussed is IGF2; the disease is type 2 diabetes mellitus.