MADA is a type of mandibuloacral dysplasia associated with mutation in the LMNA gene, while MADB is associated with ZMPSTE24 gene coding for cysteine proteinase (prenyl protease 1 homolog), which among other functions, is responsible for maturation of prelamin A by cleaving off the farnesylated C-terminus. The gene discussed is LMNA; the disease is mandibuloacral dysplasia.