In conclusion, our findings suggest that CG200745 can effectively reverse the progression of renal injury in the DSH rat model by exerting anti-inflammatory, anti-fibrotic, and anti-apoptotic effects by attenuating ED-1 overexpression, downregulating TGFβ/Smad signaling, and reducing the Bax/Bcl-2 ratio in DSH rat kidneys. The gene discussed is TGFB1; the disease is dyschromatosis symmetrica hereditaria.