Toxicities linked to anti‐VEGF treatments (eg, hypertension, vascular events and proteinuria) were reported as expected in our study and incidences were similar to or lower than those reported for VELOUR, including hypertension (41% in both, all grades) including a remarkably lower incidence of grade 3/4 events in our study of 3.8% (all grade 3) vs 19% in VELOUR, proteinuria (62% vs 40%) and diarrhea (64% vs 69%, with grade 3/4 of 6.4% vs 19%). The gene discussed is VEGFA; the disease is hypertensive disorder.