VGF and cancer: Nerves in PDAC tissues, however, showed a spectrum of SCG2 and VGF expression; the nerves outside the tumor/stromal mass did not usually express VGF or SCG2 (Fig. 2B/H), and nerves within the tumor showed weak to moderate expression (Fig. 2C/I), while nerves invaded with cancer displayed in the majority of cases moderate to strong expression (Fig. 2D/J) that was significantly higher than in noninvaded nerves (Fig. 2E/K).