In spite of the effects of USP7 inhibitors on multiple proteins, inhibitors of USP7 have been shown to be effective at raising p53 levels in cancer cells, and three such inhibitors, HBX 41108 (Colland et al., 2009), P22077 (Altun et al., 2011), and P5091 (Chauhan et al., 2012) led to p53-dependent effects on cell viability. The gene discussed is TP53; the disease is cancer.