Regardless of the mechanism responsible for the activation of p53, the premise that CDK7/9 inhibition leads to activation of p53 is supported by studies using a new small molecule targeting CKIα as well as CDK7/9, which has recently shown to cure AML in mice through a mechanism that involves p53 activation (Minzel et al., 2018). This evidence concerns the gene TP53 and acute myeloid leukemia.