CPSF1 and Retinal dystrophy: In a comparative analysis of WES data, six LoF variants in CPSF1 were detected in six of 623 probands with eoHM, but none were detected in the 2657 probands with other forms of genetic eye diseases included 1139 with inherited retinal dystrophy, 812 with glaucoma and 706 with other genetic eye diseases; this difference in variant detection was significant (P = 4.60 × 10-5, Fisher’s exact test).