PRPF8 and retinitis pigmentosa 1: In addition, both truncation and missense mutations in PRPF8 have been reported to cause adRP, but the pathogenicity of missense mutations in PRPF8 is suspicious in some cases since missense variants in PRPF8 are common based on the gnomAD database; rare damaging variants in PRPF8 had a sum allele frequency of 2.17 × 10−3 (614/282896), which is higher than the prevalence of RP (1/3000).