TF and cancer: We present EnhancerDB database that provides (i) identification of human enhancers in multiple normal or cancer tissues/cell lines; (ii) identification of the TF–enhancer, enhancer–miRNA, enhancer–gene, TF–microRNA and TF–gene interaction and related expression regulation across multiple tissues/cell lines; (iii) the potential impact of SNPs within the enhancer or affecting TFBSs located on an enhancer; and (iv) tools for users to screen customized confidence and specific/ubiquitous enhancers and links to external useful resources.