Herein, we report that the ZDF rat which develops frank type 2 diabetes with hyperglycemia, hyperinsulinemia and obesity at 20 weeks of age shows elevated PAP, PA remodeling, RV hypertrophy and bmpr2 downregulation making this animal a suitable model to study the association between glucose and lipid metabolic dysregulation and pulmonary hypertension. This evidence concerns the gene BMPR2 and pulmonary arterial hypertension.