FBXW7 and neoplasm: Unlike tumor expressed MCPyV LT-t, we were able to observe a weak interaction between MCPyV LT and Fbw7; however, this interaction was only observed unidirectionally, was independent of proposed LT binding domains and the Fbw7 WD40, did not lead to destabilization of LT, and has no relevance to transformation and tumorigenesis.