Fig 11D summarizes the phenotypic representation of the system in response to various TGF-β and IFN-β stimuli. The majority of the bi-stable region resides in the lower left corner of the G − S plane. Therefore, the biochemical fluctuation of both TGF-β and IFN-β levels in the lower regime is likely to generate a selection process of either promoting or suppressing tumor growth based on the initial distribution and phenotypic status of TANs in tumor microenvironment. This evidence concerns the gene TGFB1 and neoplasm.