This observation is consistent with previous studies in several neurological diseases, which reported correlations between CC disruption and cognitive or memory dysfunction.50, 51, 52 Surprisingly, SMI32/MBP ratio, an excellent parameter for white matter integrity in adult brain,53 was poorly correlated with the cognitive performance of neonatal rats after H/I, probably due to the simultaneous loss of both myelin and axons in the neonatal brains. This evidence concerns the gene MBP and nervous system disorder.