The results of the pooled analysis revealed that elevated LDH levels were correlated with gender (male versus female) (OR = 0.68, 95% CI: 0.49-0.95, P = 0.025), worse Child-Pugh grade (B versus A) (OR = 1.90, 95% CI: 1.47-2.45, P < 0.001), higher AFP levels (high versus low) (OR = 1.52, 95% CI: 1.26-1.82, P < 0.001), vascular invasion (yes versus no) (OR = 1.59, 95% CI: 1.36-1.86, P < 0.001), advanced TNM stage (III+IV versus I+II) (OR = 1.62, 95% CI: 1.28-2.05, P < 0.001), and larger tumor diameter (>5 cm versus <5 cm) (OR = 2.03, 95% CI: 1.23-3.35, P = 0.006). Here, AFP is linked to neoplasm.