PEBP1 and heart failure: Concomitantly, Tg-RKIP mice with FVB background showed symptoms of heart failure, which was documented by a severely decreased left ventricular ejection fraction of 30.4 ± 3.5% and 25.1 ± 4.7% in Tg-RKIP1 and Tg-RKIP2 mice (Figure 7D).