Several proteins (bands) were shown to be induced by PCN033 infection, and one at around 100 kDa was identified as ACTN4 (a type of cytoskeleton-associated protein), through mass spectrum (MS) analysis (Supplementary Figure 4A), suggesting that EGFR might recruit additional ACTN4 protein upon PCN033 challenge. The gene discussed is ACTN4; the disease is infection.