But in current study, we demonstrated that meningitic E. coli infection caused an increased recruitment of ACTN4 to the activated EGFR which is independent of the actin, and the actin fibers might become disrupted or fragmental without this “scaffold protein” ACTN4, which is consistent with the finding in another study (Sun et al., 2016). Here, EGFR is linked to escherichia coli infection.