MiR-125b and miR-504 are direct negative regulators of p53 as they bind to the 3′UTR of TP53 mRNA, and their overexpression lead to downregulation of the endogenous level of p53 protein, inhibiting apoptosis in human neuroblastoma, and lung fibroblast cells (55, 56). This evidence concerns the gene TP53 and neuroblastoma.