Indeed, several chemotherapeutic drugs and radiation are known to be able to induce senescence in tumor cells (60, 61), including inhibitors of CDK4, aurora kinase B (AURKB), casein kinase 2 (CK2), and sunitinib, a known multi-targeted receptor tyrosine kinase inhibitor (56, 62). This evidence concerns the gene NTRK1 and neoplasm.