Gene mutations like EGFR gene mutation (10–15% nsclc), KRAS mutations (10–15% nsclc) and ALK gene rearrangement (5% nsclc); Proteins like Epidermal growth factor receptor (EGFR), abnormal ALK protein; are some of the targets in NSCLC that essentially have modernized the concept of personalized medicine (5). This evidence concerns the gene ALK and non-small cell lung carcinoma.