ADCY10 and cancer: Interestingly, both decreased and increased SAC gene expression are found in tumors in mice (Sotillo et al., 2007; Ricke et al., 2011), in addition mutations in MAD1, MAD2, BUB1, BUBR1, and BUB3 are found in human cancers and over expression of the same genes is associated with elevated proliferation index and metastatic potential in several solid tumors (Yuan et al., 2006; Wang et al., 2015).