ASPM and autosomal recessive primary microcephaly: Autosomal primary recessive microcephaly (MCPH) is a disorder in neurogenesis caused by at least nine genes, six of which encode centrosome components (CEP63, CEP135, CEP152, CDK5RAP2/Cnn, CPAP /MCPH6, and STIL/MCPH7) and two encode proteins associated with spindle poles (ASPM and WDR62) (Gilmore and Walsh, 2013).