The homozygous Ppp1r3c ablated mice displayed reduced glucose and insulin levels after long-term high fat diet (HFD) reflecting an increased insulin sensitivity by the way of reducing hepatic glucose output (Lu et al., 2014); glucose tolerance and insulin sensitivity were found to be improved in Hdac9 genetic ablated mice (Chatterjee et al., 2014) suggesting the anti-diabetes function of Ppp1r3c or Hdac9 ablation. This evidence concerns the gene HDAC9 and diabetes mellitus.