DNMT1 and reproductive system disorder: Our promising findings of TCDD-induced differential methylation in reproductive disease, gene expression, and cell morphology and development pathways correspond with our phenotypic and transcriptomic outcomes and are not unexpected, considering recent findings that disruption of DNA methylation during gonad development can lead to changes in reproductive and epigenetic genes, such as increases in dnmt1 in adult zebrafish (Ribas et al., 2017).