The most common grade 3–4 adverse events were hypertension (18.2%, 10%), increased alanine aminotrasferase (ALT) (18.2%, 20%), increased aspartate aminotransferase (AST) (9.1%, 20%), diarrhea (9.15, 20%), and fatigue (9.1%, 15%) in the N+S and N+P arms, respectively. The gene discussed is GPT; the disease is hypertensive disorder.