VEGFA and hereditary clear cell renal cell carcinoma: The advent of multi-tyrosine kinase inhibitors (TKIs) or antibodies targeting the VEGF axis clearly had a significant and broad impact on the natural history of advanced renal cell carcinoma; however, durable response is rare (5–14), and therefore the development of new options that are tolerable and have the potential for durable responses remains an area of active investigation.