Indeed, it has been shown that high-affinity SHM IgG autoantibodies exacerbate SLE symptoms compared to IgM autoantibodies (50, 51), which is consistent with the presence of IgG depositions in the renal glomeruli of the TRAF3/BCL2 double-tg mice. The gene discussed is CD40LG; the disease is systemic lupus erythematosus.