Interestingly, intraperitoneal (I.P.)inoculation of pristane, a natural saturated terpenoid alkane known to promote autoimmune diseases and plasmacytoma in mice (29, 30), into TRAF3-tg mice resulted in increased tertiary organs formation and exacerbated autoimmunity, but other than a few cases of plasmacytoma, this treatment failed to promote manifest development of myeloma or other B-cell neoplasms (14). This evidence concerns the gene TRAF3 and autoimmune disease.