Signal transduction pathways may also be shared by cancer and fibrosis, as highlighted by the recent gene profiling study by Dolcino et al. revealing oncogenic signature in SSc patients, involving numerous well-known oncogenic proteins such as Ras, janus kinase (jak), Avian Myelocytomatosis Viral Oncogene Homolog (c-myc), B-cell lymphoma (bcl-2), Myeloid differentiation primary response 88 (myd88), poly(ADP-ribose) polymérase (PARP), and the phosphatidylinositol 3-kinase/Akt (PI3K/Akt) pathway (77). This evidence concerns the gene AKT1 and cancer.