Studies have proved several diseases related with the dysregulation of the actin cytoskeleton, including the Wiskott-Aldrich syndrome (WAS), an immunodeficiency disease resulted from the deficiency of WAS protein (WASP), an important actin regulator in haematopoietic cells, or WASP interacting protein (WIP) (23–26). Here, WIPF1 is linked to immunodeficiency disease.