SELE and neoplasm: However, more generally, because E-selectin expression is characteristically upregulated in tumor endothelial beds (35–46), higher E-selectin binding would increase the ability of CAR-T cells targeting a pertinent malignant cell type to enter relevant lesional tissue [i.e., for solid malignancies (e.g., breast, colon, and lung) and lymphoid malignancies (lymphomas and Hodgkin's disease)].