LGALS3 and rheumatoid arthritis: In a model of antigen-induced arthritis, Forsman and colleagues found that joint inflammation and bone erosion were attenuated, antigen-specific IgG and pro-inflammatory cytokines TNF-α and IL-6 were decreased, and the number of Th17 cells was significantly reduced in Lgals3−/− vs. WT mice, suggesting a pathogenic role for this lectin in the development and progression of RA (44).