ERN1 and melanoma: As illustrated in Figure 1G, BMDCs cultured in presence of GMCSF (“GMCSF-BMDCs”), which are an heterogeneous culture of antigen presenting cells phenotypically different to FL-DCs (Supplemental Figure 1B) (37), also induce the expression of Xbp1s and Bip upon stimulation with B16 lysates, indicating that several DC subtypes can activate the IRE1α/XBP1s axis upon melanoma cell recognition.