The APOBEC family includes 11 members in humans: activation-induced cytidine deaminase (AID), APOBEC1, APOBEC2, APOBEC3A-H, and APOBEC4, which, through their cytidine deaminase activity, are involved in diverse physiological processes including lipid metabolism, antibody diversification, virus/retroelement restriction, and cancer genome hypermutation (9–13). This evidence concerns the gene AICDA and cancer.