CSF2 and Increased total eosinophil count: In most cases secondary eosinophilia represents a reaction to the overproduction of the eosinophilopoietic cytokines such as interleukin 3 (IL-3), interleukin 15 (IL-5), and granulocyte colony stimulating factor (GM-CSF), such as the eosinophilia observed in response to allergens, drugs or parasitic infections.