CD4 and neoplasm: A negative correlation between tumor size and the abundance of both CD3+ (r2 = –0.87, p < 0.0001, Supplementary Figure S3B), CD8+ (r2 = –0.84, p < 0.0001, Supplementary Figure S3C), CD4+ (r2 = –0.85, p < 0.0001, Supplementary Figure S3D) and FOXP3+ (r2 = –0.88, p < 0.0001, Supplementary Figure S3E) cells was observed.