In addition, when we specifically investigated the local immune response, we observed a specific up-regulation of Foxp3 in mice treated with BL23 and a negative correlation between tumor size and levels of CD3+ Moreover, in tumor-bearing mice, IL-2 and CD3+ levels were positively correlated with each other, suggesting that in mice with large tumors, CD3+ levels may decrease as a result of IL-2 dependence. The gene discussed is FOXP3; the disease is neoplasm.