One may now consider that transient cryptorchidism has a reduced secretion of INSL3 at birth, and that thanks to the postnatal LH wave (that correlates with it in both studies), it will be normalized at 3 months, contributing with normal Leydig cells, to the spontaneous testicular descent, as illustrated and proposed by Bay et al. (24). This evidence concerns the gene PLOD1 and cryptorchidism.