DRD2 and schizophrenia: Since DRD2 neuronal signaling is mediated by a number of partner molecular elements downstream of the receptor, including proteins belonging to cAMP-dependent and cAMP-independent pathways, such as AKT1, GSK3B, PPP2R2B, and CTNNB1, not surprisingly also genes coding for such proteins have been associated with phenotypes that are relevant to schizophrenia pathology.