In particular, genetics studies on schizophrenia endo-phenotypes, i.e., behavioral and/or neuroimaging phenotypes associated with the disorder, have suggested that variations in genes coding for this cluster of receptors, especially those coding for DRD2, DRD3, and DRD4, are associated with cognitive deficits and related brain pre-frontal cortex malfunction, which are typical phenotypes of schizophrenia. The gene discussed is DRD4; the disease is schizophrenia.