Since DRD2 neuronal signaling is mediated by a number of partner molecular elements downstream of the receptor, including proteins belonging to cAMP-dependent and cAMP-independent pathways, such as AKT1, GSK3B, PPP2R2B, and CTNNB1, not surprisingly also genes coding for such proteins have been associated with phenotypes that are relevant to schizophrenia pathology. The gene discussed is AKT1; the disease is schizophrenia.