Diet supplementation with CA to HF diet fed C57BL/6J mice prevents, and even reverts, diet induced obesity, related to increased energy expenditure and the induction of TGR5 receptor, which increases cAMP production, involved in increased expression of genes coding for proteins related to BAT activation (PGC1α and β, UCP1 and 3, 2 iodothyronine deiodinase—D2–, straight-chain acyl-CoA oxidase 1—ACO—and muscle-type carnitine palmitoyltransferase 1—mCPT1), therefore showing activation of thermogenesis in BAT (Watanabe et al., 2006). The gene discussed is UCP1; the disease is obesity due to melanocortin 4 receptor deficiency.