UCP1 and obesity due to melanocortin 4 receptor deficiency: Considering that BAT has been recently found also in adult human and its (re)activation may be useful to counteract obesity (Nedergaard et al., 2007; Cereijo et al., 2015), the finding that PFCs directly activates BAT can be useful to enable the development of substances that selectively activate UCP1 allowing recruitment of BAT to ameliorate obesity problem (Shabalina et al., 2016).