UCP1 and obesity due to melanocortin 4 receptor deficiency: On the other, BAT is characterized by brown multilocular adipocytes and is involved in the activation of thermogenesis due to the presence of the uncoupling protein 1 (UCP1), that may be useful for increasing energy expenditure (Ricquier, 2005; Richard, 2007; Marcelin and Chua, 2010; Busiello et al., 2015) and avoiding excessive lipid accumulation in WAT, counteracting obesity and metabolic diseases development (Cannon and Nedergaard, 2004; Nedergaard et al., 2007; Saito et al., 2009; Ouellet et al., 2011; Lombardi et al., 2015).