KCNH2 and Familial short QT syndrome: Finally, whilst the 1:1 mutant to WT ratio, which was intended to represent the heterozygous state of the proband, may represent an oversimplification of the real hERG channel population in SQT1, the approach adopted in this and our previous studies (Adeniran et al., 2011, 2017; Whittaker et al., 2017a) reproduced quantitatively QT interval shortening and T wave morphology in SQTS conditions which was concordant with clinical observations.