Wang et al. (2013, 2018) reported that the expression of sEH was increased in renal tissues in the patients with glomerulonephritis when compared with the control renal tissues by IHC analysis. Both mRNA and protein levels of sEH were found higher in the kidneys of SHR than those of the control WKY rats (Yu et al., 2000; Koeners et al., 2011). The sEH was also upregulated in the renal cortex by angiotensin-II, two-kidney-one-clip, and a HFD (Imig et al., 2002; Zhao et al., 2004; Kopkan et al., 2012; Luo et al., unpublished). This evidence concerns the gene EPHX2 and glomerulonephritis.