Importantly, despite the mechanism through which NPQ-C6 circumvented IM-resistance was not explored, NPQ-C6 inhibited pYBCR-ABL1, pYSTAT5, c-MYC or PIM-1 in K562-R cells, which suggests that NPQ-coumarin conjugates might be able to circumvent resistance to TKI in BCR-ABL1+ leukemia. This evidence concerns the gene ABL1 and leukemia.