In this study, we report the NPQ-coumarin hybrid compound 7-(3,4-dimethoxyphenyl)-6H,7H-benzo[h]chromeno[4,3-b]chromene-6,8,9-trione (NPQ-C6) as a unique inhibitor BCR-ABL1-STAT5 oncogenic pathway that was effective against IM-resistant CML cells. This evidence concerns the gene BCR and chronic myelogenous leukemia, BCR-ABL1 positive.