In a controlled study on CACR intervention in schizophrenia patients, Bosia et al. (2007) found how COMT polymorphism might predict cognitive gain after 3-months follow-up, with a higher improvement in the Quality of Life Scale (QLS) in Met polymorphism after CR in comparison to Val/Val polymorphism after standard treatment. The gene discussed is COMT; the disease is schizophrenia.