In the current study, we found for the first time that the phosphorylation of Akt and mTOR as well as the expression of GluR1 decreased in PFC of OB mice, consistent with the results in the chronic mild stress model and the postpartum depression model (Li et al., 2011; Tang et al., 2015; Xia et al., 2016). This evidence concerns the gene AKT1 and postpartum depression.