The expression of NR1 in the PFC or hippocampus was up-regulated in mice of chronic mild stress, learned helplessness and pre-pregnancy stress depression models (Autry et al., 2011; Tang et al., 2015; Xia et al., 2016), and here we provided consistent evidence in OB mouse model, supporting the association of upregulated NR1 expression with depression-like behavior. This evidence concerns the gene GRIN1 and depressive disorder.