The flavonoid HMC inhibited gout-induced inflammatory pain reducing synovitis, leukocyte recruitment, oxidative stress, inflammatory cytokines (TNFα, IL-1β, and IL-6) and inducing Nrf2 activation and HO-1 mRNA expression in mice (Ruiz-Miyazawa et al., 2018a). Here, HMOX1 is linked to gout.