To further characterize if cannabinoid signaling alterations may contribute to overactive mTORC1 in FCD Type II, we performed single nucleotide polymorphism (SNP) analysis of various genes of the ECS including the CB1 receptor, DAGL alpha and beta, MAGL, FAAH and CB2 receptor (Supplementary Table 3). This evidence concerns the gene DAGLA and isolated focal cortical dysplasia type II.