SGPL1 and pulmonary fibrosis: Huang et al. (2015) structured a mouse model of partial deletion of S1PL gene and found that those mice reacted more violently to bleomycin-induced pulmonary fibrosis and the expression of autophagy-related markers, LC3 and beclin 1, are reduced when their lung S1P increases; however, the overexpressed S1PL can reduce S1P and increase the level of autophagy-related markers.