Here, we summarize major recent results: (1) PD-L1 expression/subcellular distribution in glioma tissues; (2) The correlation between PD-L1 level and survival time of glioma patients; (3) The relationship between PD-L1 and immune cell infiltration; (4) The mechanism controlling PD-L1 expression and its intracellular oncogenic role; (5) The therapeutic effects of PD-1 antibodies in patients and PD-L1 antibodies in animals. The gene discussed is CD274; the disease is central nervous system cancer.