Only tumor cells showed positive PD-L1 signals on cell membranes: 60.6% of all specimens contained >1% PD-L1+-glioma cells, 38.3% contained >5% PD-L1+-glioma cells, 17% contained >25% PD-L1+-glioma cells and 5.32% contained >50% PD-L1+-glioma cells. This evidence concerns the gene CD274 and central nervous system cancer.