In fact, the methylation level of PD-L1 promoter in IDH-mutant glioma was higher than that in IDH-wild type glioma, and PD-L1 expression negatively correlated with PD-L1 promoter methylation level (Berghoff et al., 2017; Röver et al., 2018). The gene discussed is CD274; the disease is glioma.