GSTM1 and chronic kidney disease: In Europe, the CREATE study randomized 603 CKD patients to early therapy and a target Hb of 13–15 g/dL or to “salvage” therapy and a target of 10.5–11.5 g/dL, only after the Hb level had decreased to less than 10.5 g/dL (Drueke et al., 2006).