Interestingly, the association of many of them with FD treatment has been validated, like dipeptidyl peptidase 4 (DPP4), nitric oxide synthase, prostaglandin G/H synthase (PTGS2), Glycogen synthase kinase 3 beta (GSK3B) (Gao et al., 2014). This evidence concerns the gene PTGS2 and Fabry disease.