APOD and early-onset autosomal dominant Alzheimer disease: The fact that EV-associated human ApoD is detected both as monomers and dimers (Figure 4), is a readout of its antioxidant activity, since it is known that a consequence of its lipid reducing activity is the formation of stable dimers (Bhatia et al., 2012) that accumulate in advanced stages of Alzheimer’s disease patients (Bhatia et al., 2013).