Interestingly, CD11c+ microglia are also found to increase in numbers during neuroinflammation and neurodegeneration, such as in animal models of multiple sclerosis (MS)—experimental autoimmune encephalomyelitis (EAE) and cuprizone induced demyelination, as well as in mouse models for Neuromyelitis Optica and Alzheimer's Disease (AD) (Butovsky et al., 2006a; Remington et al., 2007; Wlodarczyk et al., 2014, 2015). Here, ITGAX is linked to Alzheimer disease.