In accordance with such preponderant role, PKR dysregulation (see Figure 1) has been implicated in cancer, neurodegeneration (Segev et al., 2013, 2015; Stern et al., 2013), inflammation, and metabolic disorders (Segev et al., 2016; Garcia-Ortega et al., 2017). Here, EIF2AK2 is linked to Other metabolic disease.