The established roles of inflammation in cancer progression (Coussens and Werb, 2002; Hanahan and Weinberg, 2011), the pro-inflammatory nature of NF-κB signaling and its multiple roles in cancer development (Taniguchi and Karin, 2018), and the identification of PKR as a stimulator of NF-κB activity (Kumar et al., 1994; Maran et al., 1994; Bonnet et al., 2000, 2006) form a strong rationale for pro-tumorigenic signaling by PKR. Here, EIF2AK2 is linked to cancer.