EIF2AK3 and Alzheimer disease: However, these findings may be ascribed to PERK, rather than PKR, since similar memory enhancement has been observed by PERK genetic reduction (viral vectors and PERK KO mice) or pharmacological inhibition (using PERK inhibitor GSK2606414) (Trinh et al., 2012; Ounallah-Saad et al., 2014; Trinh et al., 2014; Sharma et al., 2018; Zimmermann et al., 2018), and also in a mouse model of AD (Ma et al., 2013; Yang et al., 2016).