While induction of oxidative stress using H2O2 in neuroblastoma cells led to increased levels of pPKR, p-eIF2α, and BACE1, in accordance with the literature, treatment with either gastrodin or a peptide PKR inhibitor prevented the increased elevation in all three parameters, indicating that gastrodin exerts its neuroprotective effect by inhibition of the PKR/eIF2α pathway (Zhang et al., 2016). The gene discussed is EIF2A; the disease is neuroblastoma.