EIF2A and Alzheimer disease: Furthermore, elevated levels of p-PKR and p-eIF2α have been observed in several mouse and monkey models of AD, including wild-type mice and cynomolgus monkeys injected with Aβ1-42 oligomers (i.c.v.), APPSwe/PS1DE9 mice, and ApoE4 mice (Lourenco et al., 2013; Segev et al., 2016).