EIF2AK2 and viral infectious disease: In addition to oncolysis resulting from productive infection (a scenario which may benefit from defects in PKR expression or function), we have recently identified a novel form of viral oncolysis (oncolysis by non-productive viral infection, ONPVI) in which the combined exposure of interferon-responsive prostate cancer cells to a novel oncolytic virus (epizootic hemorrhagic disease virus-Tel Aviv University, EHDV-TAU) and interleukin-6, induced caspase-mediated cell death.